Parkinson’s illness medications increase danger of compulsive gambling, shopping, binge consuming

Drugs frequently prescribed to alleviate Parkinson’s condition have actually been connected to impulse control disorders such as pathological gambling, compulsive buying, hyper sexuality and binge consuming in some patients, report neurologists from Loyola Medicine and Loyola University Chicago Stritch School of Medicine.


These conditions can have disastrous personal, professional and monetary repercussions if not recognized or treated, scientists report in the journal Expert Review of Neurotherapeutics. Authors of the paper include Jos Biller, MD, and first author Adolfo Ramirez-Zamora, MD, who finished a residency in neurology at Loyola.

The article information the latest findings for alleviating impulse control disorders (ICDs) in Parkinson’s illness patients, including adjusting medications, deep brain stimulation and a counseling technique called cognitive behavior modification.

One huge, previous national research found that approximately 14 percent of Parkinson’s disease clients experience a minimum of one ICD. The disorders are more common in men. Men are more likely to show hyper sexuality and pathological gambling, while women are more likely to show compulsive consuming and purchasing. Possibly disastrous repercussions consist of financial mess up, divorce and loss of employment.

Clients typically do not have understanding and underestimate the existence and intensity of ICDs and relevant conditions, the authors compose. ICDs are probably more common in Parkinson’s illness patients than formerly reported.

The primary danger aspect for ICDs is the use of a class of Parkinson’s condition medications called dopamine agonists, which help manage tremors and other Parkinson’s symptoms. These drugs include pramipexole (Mirapex) and ropinirole (Requip). Other danger factors include more youthful age, cigarette smoking, alcohol abuse and characteristic such as impulsivity, obsessive-compulsive condition, depression and anxiety.

Management of ICDs is especially difficult and no treatment standards for ICDs in Parkinson’s clients are readily available. Treatment must be individualized, and cautious selection of certain interventions is vital. Treatments that have actually been considered include changing, reducing or stopping Parkinson’s medications. However this can be challenging. Patients frequently are reluctant to change medications because they do not want their trembling to get even worse. Clients also can experience withdrawal symptoms when removed dopamine agonists, consisting of anxiety, anxiety attack, depression, irritability and fatigue.

The authors discuss alternative treatment techniques for Parkinson’s illness and medications that might help control ICD’s, such as antidepressants, irregular antipsychotics and antiepileptic drugs. Other potential nondrug treatments consist of cognitive behavioral therapy and a “brain pacemaker” called deep brain stimulation. The authors offer a much-needed, practical and detailed review of the elements essential making management decisions

Spouses and other household members ought to be warned that Parkinson’s medications can trigger ICD’s. Families must report to the patient’s physician any “unexplained absences, changes in routine habits, irritability, concealing proof of the impulse control conditions and monetary effects,” the authors compose.

Dr. Biller is chair of the department of neurology of Loyola University Chicago Stritch School of Medicine. Dr Ramirez-Zamora, a former resident in Loyola’s department of neurology, is now at Albany Medical College and functions as the Phyllis E. Duke Endowed Chair in Movement Disorders. Other co-authors are Lucy Gee of Albany Medical College and James Boyd, MD, of the University Of Vermont College Of Medicine.